The aim of this Master’s Thesis is to obtain new multicomponent pharmaceutical solids containing the active ingredient etenzamide, which belongs to the therapeutic group of non-steroidal anti-inflammatory drugs (NSAIDs), in order to improve its solubility and therefore its oral bioavailability. For this purpose, we selected the 6 co-formers most likely to form a cocrystal with this active ingredient, namely Hydroquinone (HQ), Catechol (CAT), Resorcinol (RES), Pyrogallol (PYR), Phloroglucinol (FLU) and Orcinol (ORC). The new solids were synthesized by mechanochemical synthesis and characterised by Powder X-ray Diffraction (PXRD), Single Crystal X-ray Diffraction (SCXRD), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Thermogravimetry (TGA). Solubility studies were conducted as were tests on stability when exposed to humidity and heat. The results obtained were very promising, since all the ethenzamide cocrystals showed an improvement in solubility compared to the active ingredient.

Keywords: multicomponent pharmaceutical solid; pharmaceutical cocrystal; etenzamide; NSAIDs; solubility

Directed by: Alicia Dominguez Martín