Cervical cancer is one of the most common types of cancer affecting women worldwide. The development of this cancer is closely related to an alteration in the balance of the microorganisms that inhabit the vagina, known as the vaginal microbiota. This alteration makes the vagina vulnerable to infections and sexually transmitted diseases such as human papillomavirus (HPV) infection, which is also a major risk factor for developing cervical cancer.
One possible therapeutic strategy would be to use probiotics to restore the balance of vaginal microbiota. Probiotics are live microorganisms that, when consumed, confer health benefits and have been shown to play an important role in regulating the immune system. Thus, this Master’s thesis aims to evaluate the effect of the metabolic products generated by the probiotic Bifidobacterium breve in a cervical cancer cell model in the presence of proinflammatory stimuli. The objective is to determine its potential as an effective, safe therapeutic strategy for cervical cancer prevention and treatment.
Keywords: Cervical cancer, vaginal microbiota, probiotics, human papillomavirus
Directed by: Ana I. Álvarez Mercado
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