Cancer is still one of the leading causes of death worldwide, and despite the increased development of chemotherapeutic drugs, they still have many limitations, making the search for new antitumor drugs essential.
Cancer cells are characterized by their uncontrolled proliferation and growth, which is why, as expected, they suffer alterations in their metabolism. These cells generally consume a large amount of glucose, amino acids and lipids. Lipids can act as a source of energy and are common components of cell membranes. The various alterations in lipid metabolism include the overexpression of a molecule known as choline kinase. Choline kinase is an enzyme, which will be one of the targets of the anticancer compounds that we will be developing in this research.
We hope that these compounds will be capable of inhibiting both the growth of cancer cells (antiproliferative activity) and cell division processes (antimitotic activity). In this way, the synthesized molecules would act simultaneously against different biological targets, and could form the basis for more effective cancer treatment.
Keywords: cancer, choline kinase, antiproliferative activity, antimitotic activity
Directed by: Luisa Carlota López Cara
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