Antimicrobials are substances that inhibit the growth of certain pathogenic microorganisms and can therefore be used in the treatment of the diseases they cause. However, some microorganisms have developed resistance mechanisms to these substances.
This poses a major threat to global health as resistance makes the antimicrobials less effective, making it more difficult to treat several infections, prolonging hospital stays and increasing mortality. This problem is becoming more serious as antimicrobial resistance is increasing worldwide to dangerous levels.
Several strategies are currently being employed in the fight against resistant microorganisms. One involves the use of new natural products produced by certain microorganisms as a source of antimicrobials. It consists of exploring new environments different from those traditionally explored. The aim is to isolate microorganisms that produce new molecules that have activity against resistant pathogens. These molecules could then be considered as candidates for drugs to treat these infections. With this in mind, this Master’s Thesis aims to analyse the activity of substances produced by previously isolated strains of a genus of actinomycetes (a type of bacteria), in order to evaluate their antimicrobial activity.
Keywords: resistant microorganisms, antimicrobial, natural products, drugs, actinomycetes.
Directed by: Ignacio González Martínez/Daniel Oves Costales
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