Insights into NPT2A-dependent phosphate transport

In a fruitful collaboration with Prof. Peter Friedman, from Pittsburgh University, we have provided insights into the mechanisms of NHERF1 phosphorylation promoted by parathyroid hormone, regulating NPT2A-dependent phosphate transport.

We have elegantly used our FLIM-sensor to follow transient phosphate kinetics within live cells upon the interaction with PTH hormone. We have provided dynamic phosphate maps, which have supported new insights into this important process.

The manuscript has been published in the Journal of Biological Chemistry.